I have had two Super Redhawks and a Encore in 454. I currently have a Super Blackhawk in 480.

I enjoy shooting the 45 Colt much more than the 454. Although the 45 Colt loads are pretty stoked up they just don't seem to have the recoil of the 454. Truthfully I can't seem to get them more dead with the 454. I ended up loading the 454 down and using the 250XTP. So I sold both and just stay with the 45 Colts.
Mind you I tried this twice.

Now the 480 Ruger Blackhawk I have shoots well and recoil is reasonable.
I shoot 275 and 350 Speer bullets out of it.