The thing I like most about the Sierra 300 grain 45 caliber bullets, they are the most accurate bullets I have found. ( in my 454) Sighting in a new scope using my standard hunting recipe, printed a clover leaf, all touching at the initial 40 yard sight in.
They are tough bullets, that hold together well. I’ve personally taken many large animals with these bullets, ( Moose, Bear, Bison , Boar) and always try to break them down with shoulder shots. I have only recovered 2 bullets, as they mostly go on thru, even on shoulder shots.