My 6.5/.284 XP and .475 Linebaugh have handled everything except elephant,hippo, croc, Cape buff, lion, eland. Took 2 800# kudu with it at 201 & 368 yds. Many smaller game. Never a problem. Everything was one shot.
Used a .375/.284 XP before I got my 6.5, but could have taken about everything with it.