If you are reloading, I would recommend the RCBS dies for 500 S&W. They are one, if not the only ones where you don't need to chop some length off the bottom of the die for loading 500 JRH rounds. If you are loading cut down 500 S&W brass, call RCBS and order a 50 AE expander die. If you use the 500 S&W expander with cut down brass that has not been inside reamed it will bind and buckle your cases.

Other than that, there really isn't much to worry about. Just about any load out of the JRH is going to be more than lethal on deer and elk sized game but it isn't a death ray. You still need to do your part and put the bullet in the correct spot.