I watched a bull take a cylinder full of 300 gr 44 mags in the chest (behind the shoulder) a few years ago. He expired, but it took a while. If I were using hard-cast, I would shoot for bone. Just my opinion.
There's a big difference between a .429 magnum and a .500 Smith. They are definitely not in the same league. That said, we should never underestimate a bison's ability to soak up lead.
