Sure they will. The .480 will put a bigger hole through the game animal. Forget muzzle energy as a measuring stick of a cartridge's lethality. It's a marketing tool for ammo manufacturers. There isn't a factory .454 load that doesn't exceed my .500 Linebaugh loads in "muzzle energy." I'll let you guess which one is more effective on big game, and it ain't the Casull!

The .480 is a great round that unfortunately got overshadowed by the brilliant marketing campaign of Smith & Wesson whose .500 was making headlines. Load a heavy (400 + grain) hardcast bullet at moderate velocities, put the bullet in the right place, and the .480 will do the job every time with no muss, no fuss, and no debilitating recoil.

You have made a wise choice, my friend!