any percieved accuracy difference is due to the differences that ruger either does/or did cut their chambers too. my gunsmith documented "looser" chambers in 45 colt in most blackhawks versus the 44 mag. the difference is that of the guns and not the caliber. both should be fine and plenty accurate. don't be confused though, there's no one in the world that can ever tell if game was shot with a .44 mag or .45 colt. size diff is irrelevant, so is any diff in accuracy.