I think the only "silly" question is the one not asked! LOL

I think it was hinted upon but never stated bluntly. The 45LC’s “standard” factory ammo isn’t nearly as potent as the 44's. As far as performance goes people forget to take that into consideration.

Comparing comparable firearms, and doing your loading homework, you might as well split hairs. Are there differences, Y-E-S! But I don’t think a game animal in the US would ever be able to tell the difference. Cast, jacketed, depleted uranium... you do your job and both of the cartridges in inquiry will do theirs.